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Related Experiment Video

Updated: Apr 11, 2026

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

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Published on: August 20, 2019

Imaging VEGF receptor expression to identify accelerated atherosclerosis.

Yared Tekabe¹, Maria Kollaros, Adam Zerihoun

¹Department of Medicine, Columbia University Medical Center, 622 West 168th St, PH 10 center rm 203, New York, NY, 10032, USA, yt2166@cumc.columbia.edu.

EJNMMI Research

|June 10, 2015

Summary

Imaging vascular endothelial growth factor receptors (VEGFRs) with a novel SPECT tracer (scV/Tc) can identify accelerated atherosclerosis in diabetic mice, showing higher tracer uptake and VEGFR expression in diabetic subjects. This approach shows promise for non-invasive diagnosis.

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Area of Science:

Cardiovascular Research
Medical Imaging
Diabetes Mellitus Research

Background:

Vulnerable plaque biology involves inflammation and neovascularization, linked to vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling.
These processes are accelerated in diabetes, contributing to advanced atherosclerosis.

Purpose of the Study:

To test if VEGFR imaging using a SPECT tracer (scV/Tc) can identify accelerated atherosclerosis in a diabetic mouse model.
To evaluate the correlation between tracer uptake and VEGFR expression in atherosclerotic plaques.

Main Methods:

Diabetic and non-diabetic apolipoprotein E null mice underwent SPECT/CT imaging after injection with scV/Tc or a non-binding control tracer.
Quantification of tracer uptake (% injected dose) in the proximal aorta was performed.
Immunohistochemical analysis characterized VEGFR-1 and VEGFR-2 expression in atherosclerotic lesions.

Main Results:

Diabetic mice showed significantly higher scV/Tc uptake in the proximal aorta compared to non-diabetic mice (P < 0.01).
Uptake measured as %ID/g in harvested aorta was also significantly higher in diabetic mice (P < 0.01).
Immunostaining revealed increased VEGFR-1 and VEGFR-2 expression in atherosclerotic lesions of diabetic mice.

Conclusions:

SPECT imaging with scV/Tc successfully identified accelerated atherosclerosis in diabetic mice.
The tracer uptake correlated with increased VEGFR expression, suggesting its utility for non-invasive assessment.
scV/Tc shows potential as a non-invasive diagnostic tool for accelerated atherosclerosis in diabetes.