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Updated: Apr 11, 2026

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Comparison of tumor markers using different detection devices.

Rong Tao¹, Shaohua Tu¹, Chong Liu¹

¹Nuclear Medicine, Putuo District Center Hospital, Shanghai, People's Republic of China.

Oncotargets and Therapy

|June 10, 2015

Summary

A new nanogold probe and protein chip method enables highly sensitive detection of four lung cancer tumor markers within 1.5 hours. This approach provides a strong experimental basis for clinical tumor marker detection.

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Area of Science:

Biochemistry
Nanotechnology
Proteomics

Background:

Tumor markers are crucial for early lung cancer diagnosis and treatment.
Advancements in biochip and nanotechnology enable rapid, sensitive multi-tumor marker detection.

Purpose of the Study:

To develop a highly sensitive method for detecting multiple lung cancer tumor markers.
To validate a novel nanogold probe and protein chip detection technique.

Main Methods:

Recruited 86 lung cancer patients and 42 healthy controls.
Utilized nanogold probes and protein chips for tumor marker detection.
Compared results with clinical electrochemiluminescence immunoassay and Dickkopf-1 (DKK1) detection.

Main Results:

Keywords:

electrochemiluminescence immunoassay lung cancer nanotechnology tumor markers

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Developed standard protein graphs with linear relationships.
Demonstrated consistency between the novel detection method and clinical assays.
Achieved highly sensitive detection of four tumor markers (CEA, CYFRA 21-1, NSE, DKK1) within 1.5 hours.

Conclusions:

A novel, rapid, and highly sensitive detection method for ultra-trace proteins (tumor markers) was developed.
The method utilizes nanogold deposition signal amplification on protein chips.
This provides an experimental foundation for improved clinical tumor marker detection.