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Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
Published on: June 4, 2017
Stem cell in alternative treatments for brain tumors: potential for gene delivery
Veronica Mariotti1, Steven J Greco1, Ryan D Mohan2
1Department of Medicine - Hematology/Oncology, New Jersey Medical School, Rutgers School of Biomedical Sciences, E-585, 185 South Orange Avenue, Newark, NJ 07103 USA.
Abstract:
Despite ongoing research efforts and attempts to bring new drugs into trial, the prognosis for brain tumors remains poor. Patients with the most common and lethal intracranial neoplasia, glioblastoma multiforme (GBM), have an average survival of one year with combination of surgical resection, radiotherapy and temozolomide. One of the main problems in the treatment of GBM is getting drugs across the blood brain barrier (BBB) efficiently. In an attempt to solve this problem, there are ongoing experimental and clinical trials to deliver drugs within stem cells. The purpose for this method is the ease by which stem cells home to the brain. This review discusses the experimental and clinical applications of stem cells for GBM. We also discuss the different properties of stem cells. This information is important to understand why one stem cell would be advantageous over another in cell therapy. We provide an overview of the different drug delivery methods, gene-based treatments and cancer vaccines for GBM, including the stem cell subset.
Insights
Stem cells offer a promising approach to deliver treatments across the blood-brain barrier for glioblastoma multiforme (GBM). This review explores stem cell properties and applications for improved brain tumor therapy.
Area of Science:
- Neuro-oncology
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Glioblastoma multiforme (GBM) remains a lethal brain tumor with poor patient prognosis.
- Current treatments (surgery, radiotherapy, temozolomide) offer limited survival benefits.
- Efficient drug delivery across the blood-brain barrier (BBB) is a major challenge in GBM therapy.
Purpose of the Study:
- To review the experimental and clinical applications of stem cells for treating GBM.
- To discuss the properties of various stem cell types relevant to cell therapy.
- To provide an overview of stem cell-based drug delivery, gene therapy, and cancer vaccines for GBM.
Main Methods:
- Literature review of experimental and clinical studies on stem cell therapy for GBM.
- Analysis of stem cell properties influencing brain homing and therapeutic efficacy.
- Synthesis of information on diverse stem cell-mediated treatment modalities.
Main Results:
- Stem cells possess inherent properties that facilitate their homing to the brain, making them attractive vectors for drug delivery.
- Various stem cell subsets are being investigated for their potential in GBM treatment.
- Stem cell-based approaches encompass direct drug delivery, gene-based treatments, and cancer vaccines.
Conclusions:
- Stem cell therapy presents a promising strategy to overcome the BBB challenge in GBM treatment.
- Understanding stem cell properties is crucial for selecting optimal cell types for therapeutic applications.
- Further research and clinical trials are essential to realize the full potential of stem cells in combating GBM.
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