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Related Experiment Video

Updated: Apr 11, 2026

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

Aptamer technology for tracking cells' status & function.

Christian Wiraja¹, David Yeo¹, Daniel Lio¹

¹Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457 Singapore.

Molecular and Cellular Therapies

|June 10, 2015

Summary

This summary is machine-generated.

Aptamers offer a novel way to track transplanted cells, providing insights into their status and function beyond simple biodistribution. This technology is crucial for advancing cancer research and regenerative medicine.

Keywords:

Aptamer Biosensor Cancer cells Cell tracking Contrast agent Immune cells Stem cells

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Last Updated: Apr 11, 2026

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

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Published on: October 6, 2022

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons

Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons

Published on: August 6, 2014

Area of Science:

Biomedical imaging
Molecular biology
Cellular biology

Background:

Accurate cell tracking is vital for cancer biology and regenerative medicine.
Existing imaging agents primarily show cell biodistribution, not cellular status or function.
Therapeutic cell transplantation requires validation of cell fate and efficacy.

Purpose of the Study:

To review aptamer-based biosensors for monitoring transplanted cell status and function.
To highlight aptamers' potential in cancer cell tracking and regenerative medicine.
To explore aptamer applications in immune cell tracking for immunotherapy.

Main Methods:

Aptamers, short nucleic acid sequences, bind specifically to target molecules.
Aptamer binding induces conformational changes detectable by imaging modalities.
This enables non-invasive monitoring of cellular targets like mRNA and surface markers.

Main Results:

Aptamers can act as biosensors to report on cell status and function.
Signal changes from aptamers provide insights into cellular processes.
This approach allows for non-invasive assessment of transplanted cells.

Conclusions:

Aptamers are promising tools for advanced cell tracking.
They offer a method to assess cell status and function in vivo.
Applications span cancer therapy, regenerative medicine, and immunotherapy.