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Related Experiment Video

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Chorea: A Journey through History.

Thiago Cardoso Vale1, Francisco Cardoso2

  • 1Movement Disorders Clinic, Medical School, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|June 10, 2015
PubMed
Summary

This review traces the historical evolution of chorea, from medieval "dancing mania" to modern understanding of Sydenham's chorea and Huntington's disease (HD). It highlights key physicians and discoveries shaping our knowledge of these neurological conditions.

Keywords:
ChoreaHuntington’s choreaSydenham’s choreahistory

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Area of Science:

  • Neurology
  • Medical History

Background:

  • Chorea's history spans from Middle Ages
  • dancing mania
  • to recognized neurological disorders.

Purpose of the Study:

  • To review the historical facts and physicians crucial to understanding chorea, Sydenham's chorea, and Huntington's disease (HD).

Main Methods:

  • Historical literature review
  • Biographical accounts of key medical figures

Main Results:

  • Traces chorea's description from ancient times through key figures like Sydenham and Charcot.
  • Details the eventual recognition of Sydenham's chorea and its link to rheumatic fever.
  • Highlights the discovery and characterization of Huntington's disease (HD), including contributions from Negrette's Venezuela project.

Conclusions:

  • The understanding of chorea has evolved significantly, differentiating conditions like Sydenham's chorea from Huntington's disease (HD).
  • Key historical figures and research endeavors have been instrumental in refining diagnoses and understanding the etiology of these movement disorders.