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Updated: Apr 11, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
Koichi Sugimoto1, Takahiro Akiyama2, Nobutaka Shimizu3
1Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka, Japan.
Aim:
To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity.
Methods:
We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks.
Results:
Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients.
Conclusion:
Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide.
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