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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

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Sulfonated Polyethylenimine for Photosensitizer Conjugation and Targeting.

Upendra Chitgupi¹, Yumiao Zhang¹, Chi Y Lo¹

¹†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.

Bioconjugate Chemistry

|June 10, 2015

Summary

Sulfonated polyethylenimine (PEI) conjugates bind selectin-expressing cells and inhibit blood coagulation. This targeted approach enables selective destruction of cells via photodynamic therapy for potential inflammation treatment.

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Area of Science:

Biomaterials Science
Nanomedicine
Immunology

Background:

Polysulfonated macromolecules interact with selectins, key adhesion molecules in inflammatory processes.
Polyethylenimine (PEI) is a versatile polymer amenable to chemical modification.

Purpose of the Study:

To synthesize and characterize sulfonated PEI-conjugated photosensitizers.
To evaluate the targeting capabilities and therapeutic potential of these conjugates against selectin-expressing cells.

Main Methods:

Branched PEI was sulfonated using chlorosulfonic acid.
Pyropheophoribide-a (a near-infrared photosensitizer) was conjugated to the sulfonated PEI.
Binding affinity to L-selectin (CD62L) and P-selectin (CD62P) overexpressing cells was assessed.
In vitro photodynamic therapy efficacy was evaluated.

Main Results:

Successfully synthesized photosensitizer-labeled sulfonated PEI conjugates.
Conjugates demonstrated specific binding to cells overexpressing L-selectin or P-selectin.
The conjugates exhibited inhibition of blood coagulation.
Targeted photodynamic therapy effectively destroyed selectin-expressing cells in vitro.

Conclusions:

Sulfonated PEI-photosensitizer conjugates are effective in targeting selectin-expressing cells.
These conjugates show potential for inhibiting blood coagulation and for photodynamic therapy applications in inflammatory conditions.