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Bromocriptine therapy for non-functioning pituitary adenoma.

D van Schaardenburg¹, F Roelfsema, A P van Seters

¹Department of Endocrinology, University Hospital, Leiden, The Netherlands.

Clinical Endocrinology

|May 1, 1989

Summary

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Bromocriptine rarely shrinks non-functioning pituitary adenomas but may stabilize or reduce growth in tumors showing recent progression. Further research is needed for this medical treatment.

Area of Science:

Endocrinology
Neurosurgery
Oncology

Background:

Non-functioning pituitary adenomas (NFPAs) can cause significant health issues.
Treatment options for NFPAs include surgery and medical therapy.
Bromocriptine is a dopamine agonist with potential effects on pituitary tumors.

Purpose of the Study:

To evaluate the efficacy of bromocriptine in treating non-functioning pituitary adenomas.
To assess bromocriptine's effect on tumor size and progression in NFPAs.

Main Methods:

Retrospective analysis of 25 patients with NFPAs treated with bromocriptine.
Bromocriptine dosage ranged from 5 to 22.5 mg/day over a mean of 18 months.
Tumor size changes were assessed using radiological findings and computerized tomography.

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Main Results:

Bromocriptine therapy resulted in tumor size reduction in 16% of patients.
Tumor progression was observed in 5 of 11 patients prior to bromocriptine treatment.
Three of these five progressing tumors showed reduction or stabilization with bromocriptine.
Tumor growth resumed in one patient after medication cessation.
Visual field improvements occurred in one patient, while another experienced deterioration.

Conclusions:

Bromocriptine has limited efficacy in reducing the size of NFPAs.
NFPAs with recent growth may respond to bromocriptine, showing size reduction or growth arrest.
Previous radiotherapy did not significantly influence bromocriptine's efficacy.