Related Experiment Video
Updated: Apr 11, 2026
Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
A comparative study of corneal endothelial structure between diabetes and non-diabetes
Background:
The corneal endothelial structure may be changed in diabetic patients, but the results were variable.
Objective:
To compare the corneal endothelial structure including endothelial cell density, polymorphism, andpleomorphism, in diabetic and non-diabetic subjects.
Material And Method:
The corneal endothelial structure of diabetic and non-diabetic subjects were measured by specular microscope (Confoscan4 (CS4), Nidek) for endothelial cell density, percentage of polymegathism, and percentage of hexagonal cells. The data were analyzed using the descriptive statistics and the unpaired t-test.
Results:
There were 171 eyes of 90 diabetic patients with the mean age of 58.49 ± 9.78 years, and 156 eyes of 90 non-diabetic subjects with the mean age of 58.98 ± 13.12 years. Three parameters of measurement revealed no significant difference (p > 0.05). The over one year diabetic patients, however demonstrated a decreased percentage of hexagonal cells statistically significant (p < 0.05), while the over two years diabetic patients demonstrated a decreased percentage of hexagonal cell and an increased percentage of polymegathism statistically signifcant (p < 0.05).
Conclusion:
The corneal endothelial structure is not different between diabetic and non-diabetic groups. When the disease progresses, however the hexagonal cells decrease at first, followed by the polymegathism. No difference shows in endothelial cell density.
