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Updated: Apr 11, 2026
Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
Design, Degradation Mechanism and Long-Term Cytotoxicity of Poly(L-lactide) and Poly(Lactide-co-ϵ-Caprolactone)
Gad Sabbatier1,2,3, Aitor Larrañaga4, Andrée-Anne Guay-Bégin2
1Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval, 1065, avenue de la Médecine, Québec City, Canada, G1V 0A6.
Abstract:
Degradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely-tuned poly(lactide-co-ϵ-caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well-known semi-crystalline poly(l-lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlights benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.
