Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Minerals01:26

Minerals

1.5K
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
1.5K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

6.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.8K
The Bone Matrix01:18

The Bone Matrix

6.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
6.2K
Network Covalent Solids02:18

Network Covalent Solids

16.4K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired vitamin D signaling reveals novel targets in tooth and alveolar bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Editorial "Enamel" Issue.

Calcified tissue international·2026
Same author

Diagnostic Indices for Epidemiological Assessment of Molar Incisor Hypomineralization: A Systematic Review.

Calcified tissue international·2026
Same author

Tetracycline Enables Visualization of Remineralization Induced by Agents Penetrating Dental Enamel.

Calcified tissue international·2026
Same author

Multiscale effects of dentinogenesis imperfecta on elastic properties and mineralization: A pilot study on primary dentin with a COL1A2 variant.

Dental materials : official publication of the Academy of Dental Materials·2026
Same author

Proquinazid, a new-generation fungicide, induces DNA damage and apoptosis via oxidative stress process in liver and kidney tissues of adult Wistar rats.

Toxicology·2026

Related Experiment Video

Updated: Mar 3, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

4.2K

[Enamel: a unique self-assembling in mineral world].

Guilhem Lignon1, Muriel de la Dure-Molla2, Arnaud Dessombz1

  • 1Laboratoire de physiopathologie orale moléculaire, Inserm UMRS 1138, centre de recherche des Cordeliers, université Paris Diderot-Paris 7, université Pierre et Marie Curie-Paris 6, université Paris Descartes-Paris 5, 15-21, rue de l'École de Médecine, 75270 Paris cedex 06, France.

Medecine Sciences : M/S
|June 11, 2015
PubMed
Summary

Enamel defects, resulting from genetic or environmental issues during amelogenesis, offer diagnostic clues for molecular disorders. These insights also drive innovations in regenerative medicine using enamel peptides.

More Related Videos

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

10.8K
Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

15.6K

Related Experiment Videos

Last Updated: Mar 3, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

4.2K
Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

10.8K
Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

15.6K

Area of Science:

  • Biomineralization
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Enamel is a unique, acellular vertebrate tissue formed on a scaffolding matrix and hypermineralized.
  • Ameloblasts, epithelial cells, orchestrate amelogenesis, secreting matrix proteins degraded during mineralization.
  • Perturbations in amelogenesis lead to specific, indelible enamel defects.

Purpose of the Study:

  • To highlight the diagnostic potential of enamel defects for molecular disorders.
  • To explore the multifaceted roles of enamel peptides in mineralization and cell signaling.
  • To underscore the implications for regenerative medicine.

Main Methods:

  • Analysis of enamel formation processes.
  • Characterization of matrix proteins and their enzymatic degradation.
  • Correlation of specific enamel defects with underlying cellular processes.
  • Investigation of enamel peptide functions.

Main Results:

  • Enamel defects serve as specific indicators of cellular or environmental perturbations during development.
  • The specificity of defects allows for retrospective determination of teratogenic events.
  • Enamel peptides exhibit diverse functions, including roles in mineralization and cell signaling.

Conclusions:

  • Enamel defects are valuable diagnostic tools for identifying molecular disorders.
  • Enamel peptides hold significant potential for innovations in regenerative medicine.