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Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases
Antonio J Herrera, Ana M Espinosa-Oliva, Maria J Oliva-Martin
1Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012- Sevilla, SPAIN, and Instituto de Biomedicina de Sevilla (IBiS-Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla. 41013-Sevilla, Spain. depablos@us.es.
Abstract:
Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.
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