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The emergence and maturation of the first apatite crystals in an in vitro bone formation system
M D Grynpas1, H C Tenenbaum, D P Holmyard
1Department of Pathology, University of Toronto.
Connective Tissue Research
|January 1, 1989
Abstract:
Using chick periosteal bone forming cultures we have followed the appearance of the first crystals during de Novo bone formation. The first detectable mineral deposits are crystalline. By x-ray diffraction and dark field imaging we found crystal length to grow from around 100 angstroms on day 4 to (135-160) Angstroms by day 8. The Ca/P ratio rose from 1.46 at day 4 to 1.60 at day 8.