Jove
Visualize
Contact Us

Related Experiment Videos

Meta-analysis: science or religion?

C L Meinert1

  • 1Johns Hopkins University, School of Hygiene and Public Health, Department of Epidemiology, Baltimore, MD 21205.

Controlled Clinical Trials
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insurance status and mortality among patients with AIDS.

HIV medicine·2017
Same author

Factors affecting attrition in a longitudinal study of patients with AIDS.

AIDS care·2006
Same author

Double-masked randomized trial comparing alternate combinations of intraoperative anesthesia and postoperative analgesia in abdominal aortic surgery.

Anesthesiology·2001
Same author

Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients.

Archives of ophthalmology (Chicago, Ill. : 1960)·2001
Same author

Estimation of gender bias in clinical trials.

Statistics in medicine·2001
Same author

Enrollment of women in cardiovascular clinical trials.

The New England journal of medicine·2001
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Meta-analyses are crucial for determining treatment safety and efficacy. Enhancing trial identification through prospective registration and standardized nomenclature is vital for improving their reliability and usefulness in clinical research.

Area of Science:

  • Clinical Research Methodology
  • Evidence Synthesis
  • Biostatistics

Background:

  • Meta-analysis is increasingly important for synthesizing clinical trial data.
  • Assessing treatment safety and efficacy relies heavily on robust meta-analytic methods.
  • Current meta-analytic practices face several impediments affecting their utility.

Purpose of the Study:

  • To discuss the challenges hindering effective meta-analyses.
  • To identify key requirements for improving the usefulness of meta-analyses.
  • To propose solutions for enhancing the identification and reporting of clinical trials.

Main Methods:

  • Literature review and critical analysis of current meta-analysis practices.
  • Identification of impediments in trial identification and reporting.

Related Experiment Videos

  • Discussion of proposed solutions for enhancing meta-analysis quality.

    • Main Results:

    • Significant impediments exist in identifying all relevant clinical trials.
    • Lack of standardized vocabulary and nomenclature complicates the retrieval of meta-analysis reports.
    • Prospective registration of clinical trials is a critical need for comprehensive identification.

    Conclusions:

    • Improving meta-analysis requires addressing trial identification and reporting issues.
    • Prospective trial registration is essential for complete evidence synthesis.
    • Standardized nomenclature will enhance discoverability and reliability of meta-analysis findings.