Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fatigue01:21

Fatigue

1.2K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.2K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

5.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
5.0K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.3K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.3K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.0K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.0K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

891
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
891
Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

694
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
694

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations Between Childhood Adversity and Pain in Breast Cancer Survivors.

Biopsychosocial science and medicine·2026
Same author

CREB gene regulation as a blood biomarker of neural sensitivity to social threat.

Brain, behavior, and immunity·2026
Same author

Sex, early life adversity, and negative self-evaluation shape the association between negative life events and depressive symptoms in adolescence.

Scientific reports·2025
Same author

Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination.

Cancer·2025
Same author

Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.

Journal of the National Cancer Institute·2025
Same author

Depression and Inflammation in Women With Breast Cancer: Risk and Resilience Factors.

Biopsychosocial science and medicine·2025

Related Experiment Video

Updated: Apr 11, 2026

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

650

Symptoms: Fatigue and Cognitive Dysfunction.

Julienne E Bower1, Patricia A Ganz

  • 1Departments of Psychology and Psychiatry/Biobehavioral Sciences, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA, jbower@ucla.edu.

Advances in Experimental Medicine and Biology
|June 11, 2015
PubMed
Summary
This summary is machine-generated.

Breast cancer survivors often experience persistent fatigue and cognitive issues after treatment. Understanding the causes and developing interventions are crucial for improving quality of life and resuming daily activities.

More Related Videos

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

20.5K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K

Related Experiment Videos

Last Updated: Apr 11, 2026

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

650
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

20.5K
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K

Area of Science:

  • Oncology
  • Cancer Survivorship
  • Neuroscience

Background:

  • Fatigue and cognitive complaints are prevalent during and after breast cancer treatment, including chemotherapy, radiation, and surgery.
  • These symptoms can significantly impair patients' ability to return to pre-illness activities and may persist long-term.
  • The increasing number of breast cancer survivors highlights the growing importance of addressing these persistent issues.

Purpose of the Study:

  • To review the current understanding of the etiology and biology of fatigue and cognitive complaints in breast cancer patients.
  • To discuss potential interventions for managing these debilitating symptoms.
  • To identify future research challenges in this area.

Main Methods:

  • Literature review of existing research on fatigue and cognitive dysfunction in breast cancer.
  • Synthesis of information regarding the biological mechanisms underlying these symptoms.
  • Analysis of current and proposed intervention strategies.

Main Results:

  • The etiology and biology of these symptoms are complex and not fully understood.
  • Various interventions exist, but their effectiveness and optimal application require further investigation.
  • Significant research gaps remain in understanding and managing long-term fatigue and cognitive impairment.

Conclusions:

  • Fatigue and cognitive complaints are significant, often persistent, challenges for breast cancer survivors.
  • Further research is needed to elucidate the underlying mechanisms and develop effective, evidence-based interventions.
  • Improving survivorship care requires a focus on mitigating these symptoms to enhance quality of life.