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Updated: Apr 11, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
The influence of bile acids homeostasis by cryptotanshinone-containing herbs
Chengcheng Gao1, Tianheng Ma1, Liqun Pang1
1Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, Jiangsu 223300, P. R. China.
Background:
Herbs might affect the homeostasis of bile acids through influence of multiple metabolic pathways of bile acids.
Objective:
To investigate the inhibition of cryptotanshinone towards the glucuronidation of LCA, trying to indicate the possible influence of cryptotanshinone-containing herbs towards the homeostasis of bile acids.
Methods:
The LCA-3-glucuronidation and LCA-24-glucuronidation reaction was monitored by LC-MS.
Results:
Initial screening showed that 100 µM of cryptotanshinone inhibited LCA-24-glucuronidation and LCA-3-glucuronidation reaction activity by 82.6% and 79.1%, respectively. This kind of inhibition behaviour exerted cryptotanshinone concentrations-dependent and LCA concentrations-independent inhibition behaviour.
Conclusion:
All these data indicated the possibility of cryptotanshinone's influence towards bile acids metabolism and homeostasis of bile acids.
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