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Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis
Hande Guclu1, Sadık Altan Ozal1, Vuslat Pelitli Gurlu1
1Department of Opthalmology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey.
Journal of Ophthalmology
|June 11, 2015
Summary
Systemic inflammation markers like the neutrophil lymphocyte ratio (N/L ratio) are elevated in optic neuritis (ON). A higher N/L ratio can help predict recurrent optic neuritis episodes.
Area of Science:
- Ophthalmology
- Neurology
- Immunology
Background:
- Optic neuritis (ON) is an inflammatory condition affecting the optic nerve.
- Understanding systemic inflammation markers in ON is crucial for patient management.
Purpose of the Study:
- To investigate the relationship between optic neuritis and systemic inflammation markers.
- To assess the predictive value of these markers for ON episode frequency.
Main Methods:
- Retrospective review of 42 acute ON patients and 40 healthy controls.
- Analysis of demographic data and laboratory markers including N/L ratio, platelet count, MPV, and RDW.
Main Results:
- Significantly higher N/L ratio, platelet counts, and RDW in the ON group compared to controls.
- A strong correlation found between N/L ratio and the number of ON episodes.
- Mean platelet volume (MPV) differed significantly between single-episode and recurrent ON patients.
Conclusions:
- Simple laboratory markers can indicate systemic inflammation in ON patients.
- Elevated N/L ratio is a potential predictor for recurrent optic neuritis attacks.
