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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Rota Viral Infection: A Significant Disease Burden to Libya
Salem Alkoshi1, Kacey Ernst2, Namaitijiang Maimaiti3
11. Dept. of Social and Preventive Medicine, Faculty of Medicine, University of Malaya , Kuala Lumpur, Malaysia.
Insights
Rotavirus diarrhea significantly impacts Libyan children under five, with an incidence rate of 640 per 100,000. This study highlights the need for rotavirus prevention strategies and potential vaccination in Libya.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Rotavirus is a leading cause of childhood mortality globally, particularly in children under five.
- Limited epidemiological data exists regarding rotavirus disease burden in Libya.
- This study aimed to quantify the rotavirus burden in Libyan children.
Purpose of the Study:
- To estimate the incidence rate of rotavirus diarrhea among children aged five years and below in Libya.
- To determine the demographic, seasonal, and clinical characteristics of rotavirus infections in Libyan children.
- To provide data for public health interventions and policy decisions regarding rotavirus in Libya.
Main Methods:
- A prospective cross-sectional study was conducted from August 2012 to April 2013 in northwestern Libya.
- Stool samples from 545 children under five with diarrhea were tested for rotavirus.
- Data on seasonality, symptoms, demographics, outcomes, and incidence rates were collected and analyzed.
Main Results:
- Rotavirus accounted for 57% of diarrhea cases in the study population.
- The incidence rate of rotavirus diarrhea was estimated at 640 per 100,000 children under five.
- Rotavirus infections were most prevalent in children under two years old and peaked during winter months.
Conclusions:
- Rotavirus infection represents a substantial public health challenge in Libya.
- Emphasis on preventive measures like hygiene and consideration of rotavirus vaccination are recommended.
- Vaccination could be a cost-effective strategy to reduce rotavirus disease burden in Libya.
Background:
Rotavirus is a common infection causing 450,000 deaths annually primarily in children 5 years and below. Despite the high burden of disease, little is known about the epidemiology of rotavirus in Libya. The aim of this study was to estimate the rotavirus disease burden among Libyan children.
Methods:
A cross-sectional study was carried out prospectively among children 5 years old and below between August 2012 and April 2013. Stool samples of children with diarrhea attending the outpatient department or admitted to the pediatric wards, at three public hospitals within the northwestern region of Libya were tested for rotavirus. The seasonality, symptomology demographics and outcomes of rotavirus cases were determined and compared to other diarrhea illnesses. An estimated incidence rate per 100,000 children aged 5 years and below was determined.
Results:
A total of 545 children with diarrhea were identified for participation. Results of rotavirus immunoassays determined 57% of cases were caused by rotavirus. Inpatients were more likely to be rotavirus positive than outpatients (58% vs. 53%, P<0.05), Most rotavirus positive cases (86%) were found among children below 2 years of age. Rotaviral cases peaked in the winter, constituting 76% of diarrheal illness in February and very few rotavirus cases in the summer months. The incidence rate of rotavirus diarrhea was estimated at 640/100,000 children aged 5 years and below.
Conclusion:
Rotavirus infection poses a significant disease burden in Libya. Preventive measures such as proper hygiene should be emphasized. Introduction of vaccination against rotavirus into the national immunization program should be examined, as it would likely be a cost-effective investment.
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