Automatic Identification of Messages Related to Adverse Drug Reactions from Online User Reviews using Feature-based
Jingfang Liu1, Pengzhu Zhang1, Yingjie Lu2
11. Antai College of Economics and Management, Shanghai Jiao Tong University , Shanghai, China.
Iranian Journal of Public Health
|June 11, 2015
Summary
This study developed an effective method to automatically identify adverse drug reactions (ADRs) from online user reviews using a combination of feature sets and the SVM classifier, achieving high accuracy and F-measure for post-marketing drug surveillance.
Area of Science:
- Computational linguistics
- Pharmacovigilance
- Machine learning in healthcare
Background:
- User-generated online content offers valuable data for post-marketing drug surveillance.
- Identifying adverse drug reactions (ADRs) from this data is crucial for public health.
Purpose of the Study:
- To develop an effective automated method for identifying ADR-related messages in online user reviews.
- To compare different feature sets and classification techniques for ADR detection.
Main Methods:
- Collected and annotated 3000 user messages from allergy, schizophrenia, and pain management communities.
- Generated N-gram-based and medical domain-specific feature sets.
- Applied Support Vector Machine (SVM), C4.5, and Naïve Bayes classifiers for ADR identification.
Main Results:
- The SVM classifier achieved an accuracy over 0.8, outperforming C4.5 and Naïve Bayes.
- Combined feature sets (N-gram and domain-specific) consistently outperformed single feature sets.
- The highest F-measure of 0.895 was obtained using combined features and the SVM classifier.
Conclusions:
- A combination of feature sets and the SVM classifier provides an effective approach for automated ADR identification from online user reviews.
- This method enhances the utility of user-generated content for drug safety monitoring.
Related Concept Videos
01:19Pharmacovigilance
2.0K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
2.0K
01:27Allergic Drug Reactions
1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
01:24Drug Toxicity: Risk factors
209
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
209
01:00Drug Toxicity: Overview
242
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
242
01:16Drug toxicity: Idiosyncratic Reactions
195
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
195
01:16Therapeutic Drug Monitoring: Overview and Classification
541
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
541