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Updated: Apr 11, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Recent advances in research of natural and synthetic bioactive quinolines
Po-Yee Chung1, Zhao-Xiang Bian2, Ho-Yuen Pun1
1State Key Laboratory of Chirosciences, Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
Abstract:
Many natural products that consist of quinoline core are found to be bioactive and the versatility of quinoline and its derivatives have attracted great attention in the field of drug development. As a result, in recent years, many green and sustainable synthetic approaches for the synthesis of structurally diverse quinolines have been developed. This review covers four main aspects, namely bioactive quinoline alkaloids, the biological activity and mechanism of action of quinoline-based compounds as well as various quinoline syntheses.
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