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Published on: January 27, 2019
In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
Stefânia Neiva Lavorato1, Policarpo Ademar Sales Júnior2, Silvane Maria Fonseca Murta2
1Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Abstract:
We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.
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