Related Experiment Video

Updated: Apr 11, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

6.0K

Long-term prognostic value of elevated pentraxin 3 in patients undergoing primary angioplasty for ST-elevation

Ozgur Akgul1, Omer Faruk Baycan, Umit Bulut

  • 1aDepartment of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital bDepartment of Cardiology, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Coronary Artery Disease
|June 11, 2015
PubMed

Insights

High pentraxin 3 (PTX3) levels predict worse outcomes in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). This indicates PTX3 is a valuable prognostic marker for long-term mortality in STEMI.

Area of Science:

  • Cardiology
  • Biomarkers
  • Myocardial Infarction Research

Background:

  • Pentraxin 3 (PTX3) is a known prognostic marker in acute coronary syndromes.
  • The long-term prognostic significance of PTX3 in ST-segment elevation myocardial infarction (STEMI) requires further investigation.

Purpose of the Study:

  • To assess the prognostic value of PTX3 in patients with STEMI undergoing primary percutaneous coronary intervention (PCI).

Main Methods:

  • Prospective enrollment of 499 STEMI patients undergoing primary PCI.
  • Classification into high-PTX3 (≥3.2 ng/ml) and low-PTX3 (<3.2 ng/ml) groups based on admission PTX3 levels.
  • Follow-up for in-hospital cardiovascular mortality and 2-year all-cause mortality.

Main Results:

  • The high-PTX3 group was older and exhibited higher in-hospital cardiovascular mortality (9.9% vs. 2.8%) and 2-year all-cause mortality (21% vs. 6.2%).
  • High admission PTX3 levels were independently associated with increased 2-year all-cause mortality (OR: 2.3, P=0.025).

Conclusions:

  • Elevated admission PTX3 levels are linked to increased in-hospital cardiovascular mortality.
  • High PTX3 levels serve as an independent predictor of 2-year all-cause mortality in STEMI patients post-primary PCI.
Abstract

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.9K
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.8K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
461
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.8K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.2K
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
420
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
327
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
685