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Localization of interleukin 6 mRNA in human tonsils by in situ hybridization
A Bosseloir1, E L Hooghe-Peters, E Heinen
1Institute of Histology, University of Liège, Belgium.
European Journal of Immunology
|December 1, 1989
Abstract:
We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.