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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Regulation of Food Intake01:30

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Related Experiment Video

Updated: Apr 11, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Obesity: epigenetic regulation – recent observations.

Marlene Remely, Ana Laura de la Garza, Ulrich Magnet

    Biomolecular Concepts
    |June 11, 2015
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    Summary

    Epigenetics, influenced by diet and lifestyle, plays a crucial role in obesity across generations. Understanding gene-environment interactions is key to tackling this epidemic.

    Area of Science:

    • Nutritional epigenetics and obesity research.
    • Gene-environment interactions in metabolic health.
    • Epigenetic mechanisms and public health.

    Background:

    • Obesity epidemic linked to genetic and environmental factors, including nutrition and lifestyle.
    • Epigenetic mechanisms are increasingly recognized as crucial for understanding obesity.
    • Epigenetic effects are significant during prenatal, postnatal, and intergenerational periods.

    Purpose of the Study:

    • To review the influence of nutrients, diet, and habits on epigenetics across life stages.
    • To examine evidence of epigenetic modifiers in adult obesity.
    • To discuss the utility of animal models in obesity epigenetics research.

    Main Methods:

    • Literature review focusing on nutritional and lifestyle impacts on epigenetics.

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  • Analysis of studies on intergenerational, transgenerational, prenatal, and postnatal epigenetic inheritance.
  • Inclusion of research on adult epigenetic modifiers and animal models.

    • Main Results:

    • Diet, nutrients, and lifestyle habits significantly influence epigenetic modifications relevant to obesity.
    • Epigenetic changes can be transmitted across generations, impacting obesity risk.
    • Animal models provide valuable insights into obesity development and epigenetic regulation.

    Conclusions:

    • Epigenetic mechanisms are vital for understanding the complex causes of obesity.
    • Interventions targeting diet and lifestyle may modify epigenetic patterns to prevent obesity.
    • Further research, including animal studies, is needed to elucidate obesity's epigenetic underpinnings.