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Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
Published on: February 25, 2021
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Lipid Nanoparticles for Ocular Gene Delivery
Yuhong Wang1,2, Ammaji Rajala3,4, Raju V S Rajala5,6,7
1Dean A. McGee Eye Institute, Oklahoma City, OK 73104, USA. yuhong-wang@ouhsc.edu.
Journal of Functional Biomaterials
|June 11, 2015
Summary
Lipid nanoparticles, including solid lipid nanoparticles (SLNs) and lipoplex (LPDs), are advanced carriers for ocular drug and gene delivery. These nanostructures show promise for treating corneal and retinal diseases.
Area of Science:
- Biotechnology
- Nanomedicine
- Ophthalmology
Background:
- Lipids are fundamental cellular components capable of self-assembly into various nanostructures like liposomes.
- Liposomes, as bilayer structures, are recognized for their drug delivery potential.
- Lipid nanoparticles, including SLNs and LPDs, are emerging as key delivery systems for ocular tissues.
Purpose of the Study:
- To review recent advancements in ocular drug and gene delivery using lipid nanoparticles.
- To highlight the application of SLNs and LPDs in treating eye diseases.
Main Methods:
- Discussion of solid lipid nanoparticles (SLNs) with solid lipid cores for solubilizing lipophilic molecules.
- Explanation of lipoplex (LPD) nanoparticles formed from cationic liposomes and DNA complexes for gene delivery.
- Overview of SLN applications in corneal drug delivery and LPD applications in retinal gene/microRNA delivery.
Main Results:
- SLNs are effective for delivering drugs to the cornea.
- LPD nanoparticles demonstrate efficacy in targeting the retina for gene and microRNA delivery.
- Promising results have been achieved in treating retinal diseases like AMD, RP, and DR using LPDs.
Conclusions:
- Lipid nanoparticles offer versatile platforms for targeted drug and gene delivery to ocular tissues.
- SLNs and LPDs represent significant progress in managing corneal and retinal diseases.
- Further research into lipid nanoparticle technology holds potential for innovative ocular therapies.
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