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Related Experiment Videos

Corneal epithelial cell movement in humans.

M A Lemp1, W D Mathers

  • 1Center for Sight/Cornea Service, Georgetown University Medical Center, Washington, DC 20007.

Eye (London, England)
|January 1, 1989
PubMed
Summary

Corneal epithelial cells move towards the center, influenced by topography and lid forces. A new hypothesis suggests upper eyelid shearing causes central cell loss, driving this movement.

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Corneal Science

Background:

  • Epithelial cell movement is crucial for corneal health.
  • Factors influencing corneal epithelial cell migration are not fully understood.

Purpose of the Study:

  • To investigate the centripetal movement of corneal epithelial cells.
  • To identify factors affecting this movement and propose a driving mechanism.

Main Methods:

  • Corneal specular microscopy was used to study epithelial morphology.
  • Analysis included normal corneas, disease states (keratoconjunctivitis sicca, neurotrophic keratitis), contact lens wear, and post-penetrating keratoplasty.

Main Results:

  • Altered epithelial morphology was observed in various conditions.
  • Vortex keratopathy was found in 70% of post-keratoplasty patients.
  • Epithelial cell pallisading around sutures indicated centripetal movement.

Conclusions:

  • Corneal epithelial cell movement is influenced by topography, disease, and lid forces.
  • A new hypothesis proposes upper eyelid shearing forces cause central cell exfoliation, driving centripetal migration.

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