Related Experiment Video

Updated: Apr 10, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

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MiRNA-based therapeutic intervention of cancer

Srivatsava Naidu1, Peter Magee2, Michela Garofalo3

  • 1Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. Srivatsava.Naidu@cruk.manchester.ac.uk.

Journal of Hematology & Oncology
|June 12, 2015
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and cell fate. Dysregulated miRNAs are linked to cancer, showing potential for novel cancer therapies and miRNA delivery strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • MicroRNAs (miRNAs) are key regulators of eukaryotic gene expression.
  • miRNAs modulate cellular transcriptome and proteome, influencing cell fate.
  • Aberrant miRNA expression is implicated in carcinogenesis.

Purpose of the Study:

  • To review the role of miRNAs in tumor development.
  • To summarize current therapeutic strategies involving miRNAs.
  • To discuss advances in miRNA delivery systems for cancer therapy.

Main Methods:

  • Literature review of recent studies on miRNAs in cancer.
  • Analysis of miRNA involvement in tumorigenesis.
  • Evaluation of therapeutic approaches and delivery methods.

Main Results:

  • miRNAs play a significant role in cancer development.
  • miRNAs hold promise as diagnostic and therapeutic targets.
  • Various strategies for miRNA delivery are under investigation.

Conclusions:

  • miRNAs are critical in cancer research and therapy.
  • Targeting miRNAs offers potential for novel cancer treatments.
  • Effective miRNA delivery is essential for therapeutic success.

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