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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Mouse Models of Rheumatoid Arthritis.

P Caplazi1, M Baca2, K Barck3

  • 1Departments of Research Pathology, Genentech Inc, South San Francisco, CA, USA caplazi.patrick@gene.com.

Veterinary Pathology
|June 12, 2015
PubMed
Summary
This summary is machine-generated.

This review details common mouse models for rheumatoid arthritis (RA), an autoimmune disease. Understanding these models aids in developing new RA therapies and treatments.

Keywords:
TNFΔ ARE mouseanimalarthritiscollagen antibody–induced arthritiscollagen-induced arthritisexperimentalk/bxn antibody transfer arthritismicemodelsrheumatoid

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Area of Science:

  • Immunology
  • Rheumatology
  • Translational Medicine

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disorder causing synovitis and joint erosion.
  • Mouse models are crucial for studying RA mechanisms and validating therapeutic targets.
  • Despite effective treatments, RA remains an active area of biomedical research.

Purpose of the Study:

  • To review and integrate morphologic features with model biology for commonly used RA mouse models.
  • To cover key characteristics of induced and spontaneous mouse models of RA.
  • To provide a comprehensive resource for researchers utilizing RA mouse models.

Main Methods:

  • Review of induced arthritis models: collagen-induced arthritis (CIA) and antibody-induced arthritis (AIA).
  • Focus on passive immunization strategies like collagen antibody-induced arthritis and K/BxN antibody transfer arthritis.
  • Examination of spontaneous models, specifically the TNFΔ (ARE) mouse with TNF-α overexpression.

Main Results:

  • CIA represents an active immunization strategy for inducing arthritis in mice.
  • AIA models, including CIA and K/BxN, exemplify passive immunization approaches.
  • The TNFΔ (ARE) mouse model demonstrates spontaneous arthritis due to TNF-α overexpression.

Conclusions:

  • Various induced and spontaneous mouse models effectively recapitulate features of human rheumatoid arthritis.
  • These models are indispensable tools for dissecting RA pathogenesis and evaluating novel therapeutic interventions.
  • Integrating morphologic and biological data enhances the utility of mouse models in RA research.