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The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

D O Yetkin1, B Dogantekin2

  • 1Department of Endocrinology, Kolan International Hospital, 36384 Istanbul, Turkey.

International Journal of Endocrinology
|June 12, 2015
PubMed

Insights

Thyroid autoimmunity, even in euthyroid Hashimoto patients, is linked to higher levels of total cholesterol, LDL cholesterol, and excess Lipoprotein(a) (Lp(a)). This suggests thyroid autoimmunity impacts lipid metabolism and cardiovascular risk.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Immunology

Background:

  • Autoimmune thyroiditis, specifically Hashimoto's disease, is associated with an increased risk of atherosclerotic heart disease.
  • Lipoprotein(a) (Lp(a)) is a recognized independent predictor of premature atherosclerotic vascular diseases.
  • The precise mechanisms linking thyroid autoimmunity to cardiovascular risk remain unclear.

Purpose of the Study:

  • To investigate the relationship between Lipoprotein(a) (Lp(a)) levels and thyroid hormone status in patients with Hashimoto's disease.
  • To determine if Lp(a) excess is more prevalent in different thyroid function states within Hashimoto's patients.

Main Methods:

  • A study involving 154 premenopausal female Hashimoto patients (categorized as overhypothyroid, subclinical hypothyroid, and euthyroid) and 50 age-matched controls.
  • Measurement of thyroid function tests, lipid parameters, and Lipoprotein(a) (Lp(a)) levels in all participants.
  • Definition of Lp(a) excess as Lp(a) > 30 mg/dL.

Main Results:

  • Hashimoto's patients exhibited elevated levels of Total Cholesterol (Total-C), LDL Cholesterol (LDL-C), Triglycerides (TG), and Lp(a).
  • Subclinical hypothyroid and euthyroid Hashimoto groups showed higher Total-C and LDL-C compared to controls.
  • Excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto patients than in the control group, despite similar Lp(a) levels.

Conclusions:

  • Elevated Total-C, LDL-C, and excess Lp(a) are present even in euthyroid Hashimoto's patients.
  • Thyroid autoimmunity may play a role in altering Lp(a) and overall lipid metabolism.
  • These findings highlight a potential link between thyroid autoimmunity and dyslipidemia, contributing to cardiovascular risk.

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