FoxM1: a novel tumor biomarker of lung cancer

FoxM1 is a member of the Forkhead box (Fox) family of transcription factors, which is expressed in actively dividing cells and is critical for cell cycle progression. Increased expression of FoxM1 was found in many tumors including non-small cell lung cancer (NSCLC). A more recent study showed FoxM1 is associated with poor prognosis of NSCLC patients through promoting tumor metastasis; elucidated FoxM1 could exert a direct effect on the prognosis of NSCLCs patients. In this review, we summarize the role FoxM1 in lung cancer in the hope of providing insights into the utility of FoxM1 as a novel biomarker of lung cancer.