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Updated: Apr 10, 2026
Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland
Published on: October 4, 2013
Treatment for displacement of PAAG mixture after injection augmentation mammoplasty
Liang Chen1, Liu Sha2, Shu-Peng Huang1
1Department of Plastic and Aesthetic Surgery, Southwest Hospital, Third Military Medical University Chongqing 400038, China.
Background:
The incidence of serious complications after augmentation mammaplasty with injection of polyacrylamide hydrogel (PAAG) was high.
Objective:
To design a new method for healing of the cavities and cysts after augmentation mammaplasty.
Methods:
102 patients in whom PAAG exceeded the breast and spread to the thoracic-abdominal walls were enrolled and divided into two groups.
Results:
The flowing masses of different sizes exceeded the breast and spread to the thoracic-abdominal walls, and a large number of PAAG showed flowing degenerative mixture in the tissues and were invaded by many inflammatory cells. PAAG deposited extensively in the breast tissues, armpits and space of the thoracic-abdominal wall, and the breast was connected with the abdominal wall through the fistula of different sizes. At 2 weeks, the percentages of decrease in drainage volume and in lesion lacuna size of the thoracic-abdominal wall (82% and 80%, respectively) in patients receiving the multiple incisions combined with radical therapy were significantly different from those who did not receive the multiple incisions (46% and 45%) (Both P<0.01). At 4 weeks, in some of the patients receiving the multiple incisions combined with radical therapy, the lacuna of the thoracic-abdominal wall disappeared completely, and the lesions with flowing masses had been cleared.
Conclusions:
The new method of subareolar incision combined with surgery for inferior segment of mass to clean the mixture and thoroughly eliminate the lacuna of the thoracic-abdominal wall as well as suture to close the intramammary fistula can improve the treatment efficacy.
