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Triglyceride to HDL-C ratio and increased arterial stiffness in apparently healthy individuals

Jiang-Hua Wen1, Yu-Yu Zhong1, Zhi-Gang Wen2

  • 1Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.

International Journal of Clinical and Experimental Medicine
|June 12, 2015
PubMed

Insights

High triglycerides and low HDL cholesterol (TG/HDL-C) are linked to arterial stiffness in healthy individuals. Increased TG/HDL-C is independently associated with abnormal brachial-ankle pulse wave velocity (baPWV), a marker of atherosclerosis.

Area of Science:

  • Cardiovascular Health
  • Biomarkers
  • Arterial Stiffness

Background:

  • High triglycerides and low high-density lipoprotein cholesterol (HDL-C) are established cardiovascular risk factors.
  • The triglyceride to HDL-C ratio (TG/HDL-C) is a potential predictor of cardiovascular disease.
  • Brachial-ankle pulse wave velocity (baPWV) measures arterial stiffness and atherosclerosis but its relation to TG/HDL-C is understudied.

Purpose of the Study:

  • To investigate the association between the TG/HDL-C ratio and baPWV in apparently healthy individuals.
  • To determine if TG/HDL-C is an independent predictor of abnormal arterial stiffness.

Main Methods:

  • 1498 healthy, medication-free subjects underwent lipid profile and baPWV measurements.
  • Participants were stratified into TG/HDL-C quartiles.
  • Multivariable logistic regression adjusted for cardiovascular risk factors to assess the association between TG/HDL-C quartiles and abnormal baPWV (>1400 cm/s).

Main Results:

  • Positive correlations were observed between TG/HDL-C quartiles and BMI, blood pressure, glucose, and lipid levels.
  • The highest TG/HDL-C quartiles showed significantly higher odds of abnormal baPWV in both men (OR 1.91) and women (OR 2.91) after multivariable adjustment.

Conclusions:

  • Elevated TG/HDL-C is independently associated with abnormal brachial-ankle pulse wave velocity in healthy individuals.
  • TG/HDL-C may serve as a useful biomarker for identifying individuals with increased arterial stiffness and subclinical atherosclerosis.
Abstract

Keywords:
Arterial stiffnesspulse wave velocitytriglyceride to HDL-C Ratio

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