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Na(+)/H(+) exchange and hypoxic pulmonary hypertension

John Huetsch1, Larissa A Shimoda1

  • 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.

Pulmonary Circulation
|June 12, 2015
PubMed
Summary

Sodium-hydrogen exchange (NHE) regulates intracellular pH in pulmonary artery smooth muscle cells (PASMCs). This review explores NHE's role in PASMC function and its therapeutic potential for treating pulmonary hypertension.

Keywords:
hypoxiaintracellular pHpulmonary vascular smooth muscle

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