Related Experiment Video

Updated: Apr 10, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.3K

Hypertension in autosomal-dominant polycystic kidney disease (ADPKD)

Laia Sans-Atxer1, Roser Torra2, Patricia Fernández-Llama3

  • 1Hypertension Unit, Nephrology Department , Hospital del Mar, Parc de Salut Mar , Barcelona, Spain.

Clinical Kidney Journal
|June 12, 2015
PubMed

Insights

Hypertension management is crucial for autosomal-dominant polycystic kidney disease (ADPKD) patients, as elevated blood pressure (BP) significantly impacts cardiovascular and renal outcomes. Early diagnosis and treatment, primarily with renin-angiotensin-aldosterone system (RAAS) inhibitors, are essential for improving patient prognosis.

Area of Science:

  • Nephrology
  • Cardiology
  • Genetics

Background:

  • Cardiovascular complications are the leading cause of mortality in autosomal-dominant polycystic kidney disease (ADPKD).
  • Hypertension is prevalent in ADPKD patients, often preceding renal insufficiency and contributing to target organ damage and poor renal prognosis.
  • Polycystin deficiency and renin-angiotensin-aldosterone system (RAAS) stimulation are implicated in ADPKD-related hypertension pathogenesis.

Purpose of the Study:

  • To highlight the critical role of hypertension management in ADPKD patients.
  • To emphasize the importance of early diagnosis and appropriate treatment strategies for cardiovascular and renal complications.
  • To provide guidance on blood pressure targets and therapeutic approaches in ADPKD.

Main Methods:

  • Review of existing literature on hypertension in ADPKD.
  • Discussion of diagnostic tools like ambulatory blood pressure monitoring.
  • Analysis of therapeutic options including non-pharmacological approaches, RAAS inhibitors, and calcium channel blockers (CCBs).

Main Results:

  • Elevated blood pressure is a key determinant of patient outcome in ADPKD.
  • Early detection of hypertension via ambulatory BP monitoring is recommended.
  • RAAS inhibitors are the primary treatment, with CCBs reserved for resistant cases.

Conclusions:

  • Prompt diagnosis and management of hypertension are vital for improving CV and renal outcomes in ADPKD.
  • Target blood pressure should be <140/90 mmHg for all ADPKD patients, with a stricter goal of <135/85 mmHg if microalbuminuria or left ventricular hypertrophy is present.
  • RAAS inhibitors are the cornerstone of antihypertensive therapy in ADPKD.

Keywords:
ambulatory blood pressure monitoringblood pressure profilecardiovascular riskpolycystic kidney diseaserenal size

More Related Videos

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

12.1K
Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay08:13

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

14.0K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.2K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.8K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.6K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
644
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
754
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.0K