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Updated: Apr 10, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

PRP Augmentation for ACL Reconstruction.

Luca Andriolo¹, Berardo Di Matteo¹, Elizaveta Kon²

¹II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.

Biomed Research International

|June 12, 2015

Summary

This summary is machine-generated.

Platelet Rich Plasma (PRP) shows promise in improving graft healing in Anterior Cruciate Ligament (ACL) surgery preclinical studies. However, clinical evidence is mixed, with no clear benefits for bone tunnel integration or short-term function.

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Last Updated: Apr 10, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

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Published on: April 30, 2014

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Published on: March 26, 2015

Harvesting of Peroneus Longus Tendon Autograft

Harvesting of Peroneus Longus Tendon Autograft

Published on: September 2, 2025

Area of Science:

Orthopedic Surgery
Regenerative Medicine
Biomaterials

Background:

Anterior Cruciate Ligament (ACL) reconstruction surgery aims to restore knee stability.
Enhancing graft healing and integration is crucial for successful surgical outcomes.
Biological augmentation strategies, like Platelet Rich Plasma (PRP), are being explored to improve healing.

Purpose of the Study:

To systematically review preclinical and clinical studies on Platelet Rich Plasma (PRP) application in ACL reconstructive surgery.
To evaluate the efficacy of PRP as a biological enhancer for graft healing and integration.
To assess the safety and functional outcomes associated with PRP use in ACL reconstruction.

Main Methods:

Systematic literature review of preclinical and clinical studies.
Inclusion of 32 relevant research papers.
Analysis of histological, biomechanical, and clinical outcomes.

Main Results:

Preclinical studies indicate PRP enhances tendinous graft healing (histological and biomechanical).
Clinical evidence is not uniform; PRP is safe and may aid donor site healing and graft maturation.
Most studies found no significant benefit in bony tunnel/graft integration or short-term functional outcomes.

Conclusions:

PRP demonstrates potential in preclinical models for improving ACL graft healing.
Clinical efficacy of PRP in ACL reconstruction remains inconclusive, particularly for graft-bone integration.
Further research is needed to clarify PRP's role and optimize its application in ACL surgery.