Related Experiment Video

Updated: Apr 10, 2026

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
08:02

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells

Published on: September 23, 2021

3.1K

[Oncotoxic proteins in cancer therapy: mechanisms of action]

Y N Lezhnin, J E Kravchenko, E I Frolova

    Molekuliarnaia Biologiia
    |June 13, 2015
    PubMed

    Insights

    Protein biomolecules offer targeted cancer therapy by selectively harming tumor cells. Oncotoxic proteins, a promising class, trigger cancer cell death by exploiting tumor-specific processes, potentially advancing cancer treatment.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Oncology

    Context:

    • Protein biomolecules are increasingly investigated for cancer therapeutics due to their selective toxicity towards tumor cells.
    • Engineered antibodies and oncotoxic proteins represent key subgroups with therapeutic potential.
    • Tumor cells exhibit distinct biological processes, including altered cell proliferation, cell-cycle control, apoptosis, mitochondrial respiration, and glycolysis.

    Purpose:

    • To review the therapeutic potential of protein biomolecules, specifically oncotoxic proteins, in cancer treatment.
    • To highlight the mechanisms by which oncotoxic proteins selectively target and eliminate cancer cells.
    • To discuss the implications of introducing oncotoxic proteins into clinical practice for cancer therapy.

    Summary:

    • Protein-based therapeutics are gaining attention for their ability to selectively target cancer cells.
    • Oncotoxic proteins are a promising subgroup that can induce programmed cell death (apoptosis) in cancer cells.
    • These proteins exploit common abnormalities in cancer cells, such as uncontrolled proliferation and altered metabolism.

    Impact:

    • The development of oncotoxic proteins could significantly expand the range of available anticancer therapeutics.
    • Targeted protein therapies offer the potential for reduced side effects compared to traditional chemotherapy.
    • Successful clinical translation of oncotoxic proteins may lead to improved patient outcomes in cancer treatment.

    More Related Videos

    Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

    Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

    Published on: January 7, 2019

    10.4K
    Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

    Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

    Published on: August 25, 2021

    2.2K

    Related Concept Videos

    Cancer-Critical Genes I: Proto-oncogenes01:33

    Cancer-Critical Genes I: Proto-oncogenes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...
    12.1K
    Cancer-Critical Genes I: Proto-oncogenes01:33

    Cancer-Critical Genes I: Proto-oncogenes

    6.3K
    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    2.5K
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against...
    9.1K
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    1.8K
    Cancer02:18

    Cancer

    Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
    56.0K