Related Experiment Video
Updated: Apr 10, 2026

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems
Published on: October 14, 2025
[The functional aspects of bacterial CRISPR-cas systems and interactions between phages and its bacterial hosts--a
Abstract:
The roles of CRIPR-Cas systems in bacterial host protection against mobile genetic elements ( MGEs) are now well known, but there is mounting evidence that these systems modulate other processes, such as the genetic regulation of group behavior and virulence, DNA repair and genome evolution. Here, we reviewed the structure, types and mechanism of interference of CRISPR-Cas system as well as the additional functions of CRISPR-Cas beyond adaptive immunity. Furthermore, we discussed the mechanisms for phages to overcome bacterial CRISPR-Cas system, and the prospective evolution of interactions between phage and host.
Related Concept Videos
CRISPR and crRNAs
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
The Antiviral System of Bacteria and Archaea: CRISPR
DNA Bacteriophages
CRISPR/Cas9 Genome Editing
Viral Replication: Lysogenic Cycle
Regulation of Bacterial Virulence

