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Analysis of Bottlenecks in Experimental Models of Infection

Sören Abel1, Pia Abel zur Wiesch2, Brigid M Davis3

  • 1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Infectious Diseases, Brigham & Women's Hospital, Boston, Massachusetts, United States of America; Department of Pharmacy, University of Tromsø (UiT), The Arctic University of Norway, Tromsø, Norway.

Plos Pathogens
|June 13, 2015
PubMed
Abstract

No abstract available in PubMed .

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Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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