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Related Experiment Video

Updated: Apr 10, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Long-term structural changes after mTBI and their relation to post-concussion symptoms.

Philip J A Dean1, Joao Ricardo Sato2,3, Gilson Vieira3

  • 1a Department of Psychology , University of Surrey , Guildford , UK.

Brain Injury
|June 13, 2015
PubMed
Summary

Mild traumatic brain injury (mTBI) can cause lasting grey and white matter damage over a year later. These structural brain changes correlate with the severity of persistent post-concussion syndrome symptoms.

Keywords:
Magnetic resonance imagingcortical thicknessdiffusion tensor imagingmild traumatic brain injurypersistent post-concussion syndrome

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Area of Science:

  • Neuroimaging
  • Neurology
  • Brain Injury Research

Background:

  • Mild traumatic brain injury (mTBI) can lead to persistent post-concussion syndrome (PCS).
  • Long-term structural brain changes after mTBI are not fully understood.
  • Investigating the link between brain structure and ongoing PCS is crucial.

Purpose of the Study:

  • To examine sustained structural alterations in the brain more than one year post-mTBI.
  • To determine the relationship between these long-term structural changes and the severity of ongoing PCS.

Main Methods:

  • Acquired magnetic resonance imaging (MRI) data focusing on morphology and structural connectivity.
  • Included 16 participants with a history of mTBI and 9 healthy controls.
  • Utilized advanced MRI techniques to assess brain tissue integrity and white matter pathways.

Main Results:

  • Participants with mTBI showed reduced prefrontal grey matter volume.
  • Lower fractional anisotropy (FA) was observed in the anterior corona radiata and internal capsule in the mTBI group.
  • PCS severity correlated with reduced parietal grey matter and decreased FA in the corpus callosum.

Conclusions:

  • Evidence suggests both grey and white matter damage persist beyond one year after mTBI.
  • Structural brain abnormalities are more pronounced in individuals reporting greater PCS symptom severity.
  • Findings indicate a potential neurophysiological basis for persistent post-concussion symptoms.