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Vaccine Production

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

Chemical Platforms for Peptide Vaccine Constructs.

Suhas Ramesh¹, Prabhakar Cherkupally¹, Thavendran Govender¹

¹Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Advances in Protein Chemistry and Structural Biology

|June 13, 2015

Summary

Researchers are developing new peptide-based vaccines by chemically tailoring fragments of pathogenic proteins. This approach aims to create highly immunogenic vaccines with fewer allergens for a stronger antibody response.

Keywords:

Chemical approaches MAPs Peptide epitopes Synthesis Vaccine

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Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

Area of Science:

Protein chemistry
Vaccinology
Immunology

Background:

Understanding pathogenic microorganism proteins is crucial for vaccine development.
Peptide-based vaccines utilize specific protein fragments (epitopes) to elicit an immune response.
Current strategies aim to enhance immunogenicity and reduce adverse reactions.

Purpose of the Study:

To summarize chemical strategies for presenting peptide epitopes in vaccine design.
To explore novel platforms for tethering antigenic epitopes.
To improve antibody response through tailored vaccine constructs.

Main Methods:

Review of chemical strategies for peptide epitope presentation.
Analysis of methods for creating novel vaccine platforms.
Focus on tailoring peptidic fragments for high immunogenicity.

Main Results:

Various chemical approaches have been investigated for vaccine development.
Novel platforms enable effective tethering of antigenic epitopes.
Chemically tailored fragments enhance immunogenicity and antibody response.

Conclusions:

Chemical strategies are vital for developing effective peptide-based vaccines.
Tailored presentation of epitopes is key to maximizing immunogenicity.
This research highlights advancements in designing next-generation vaccines.