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Updated: Apr 10, 2026
04:36
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
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Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters
Arend-Jan Meinders1, Laurens Nieuwenhuis, Can Ince
1Department of Internal Medicine and Intensive Care Unit, St. Antonius Hospital, Nieuwegein, The Netherlands.
Blood Purification
|June 13, 2015
Summary
Hemodialysis commonly causes hemodynamic changes, impairing microvascular blood flow and oxygen delivery. This study used advanced imaging to reveal significant microcirculatory disturbances during dialysis.
Area of Science:
- Nephrology
- Physiology
- Medical Imaging
Background:
- Hemodynamic changes are frequent during hemodialysis.
- Symptoms are often linked to reduced microcirculatory blood flow and oxygen delivery.
- The impact of hemodialysis on microcirculation is under-researched.
Purpose of the Study:
- To investigate the effects of hemodialysis on central microvascular blood flow.
- To analyze microcirculatory alterations using novel imaging techniques.
Main Methods:
- Observational study design.
- Utilized Sidestream Dark Field (SDF) imaging, a microscopic technique.
- Visualized erythrocyte passage through sublingual capillaries to assess microvascular flow.
Main Results:
- Demonstrated substantial impairment of microvascular blood flow during hemodialysis.
- Observed a discrepancy between microvascular and macrovascular parameters.
- Highlighted the impact of hemodialysis on the microcirculation.
Conclusions:
- Hemodialysis significantly affects microcirculatory blood flow.
- There is a notable difference between macro- and micro-vascular responses to hemodialysis.
- Further research into microcirculation during dialysis is warranted for patient outcomes.
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