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Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

Kongyang Ma1, Jingyi Li2, Yongfei Fang3

  • 1Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China. kongyang@hku.hk.

International Journal of Molecular Sciences
|June 13, 2015
PubMed

Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.

Keywords:
B-1 B cellsUnc-93 Homolog B1 (C. elegans) (Unc93b1)anti-nuclear autoantibody (ANA)germinal center B cells (GC B cells)marginal zone B cells (MZ B cells)memory B cellsmyeloid differentiation primary response gene 88 (MyD88)systemic lupus erythematosus (SLE)toll-like receptor (TLR)transitional B cells

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