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Mumps disease outbreak in Davangere district of Karnataka, India

C G Raut1, D P Sinha, H Jayaprakash

  • 1National Institute of Virology, Bangalore Unit, Bangalore Near NIMHANS, Karnataka - 560 029, India.

Indian Journal of Medical Microbiology
|June 13, 2015
PubMed
Abstract

Insights

This study confirmed mumps virus genotype C in an Indian outbreak using serology and RT-nested PCR. The findings aid in understanding mumps epidemiology and control in the region.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Mumps is a vaccine-preventable viral illness.
  • Complications include pancreatitis, meningitis, and encephalitis.
  • Outbreaks are uncommon in India despite global prevalence.

Purpose of the Study:

  • To diagnose and characterize mumps cases in an unimmunized Indian population.
  • To identify the specific genotype of the mumps virus responsible for the outbreak.

Main Methods:

  • Clinical data collection from 31 suspected cases.
  • Laboratory testing included mumps IgM antibody detection and RT-nested PCR for viral RNA.
  • Sequencing of the SH gene for molecular identification.

Main Results:

  • 18 out of 31 cases were positive for mumps IgM antibodies.
  • 7 cases showed mumps virus RNA by RT-nested PCR.
  • Sequencing identified the outbreak strain as genotype C.

Conclusions:

  • Mumps infection was confirmed using serological and molecular methods.
  • The identified genotype C aligns with other reported Indian mumps outbreaks.
  • This study provides crucial data for mumps surveillance and control strategies in India.

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