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Kluyvera ascorbata sepsis in an extremely low birth weight infant

D Sharma1, T Dasi, S Murki

  • 1Department of Neonatology, Fernandez Hospital, Hyderguda, Hyderabad - 500 029, Telangana, India.

Indian Journal of Medical Microbiology
|June 13, 2015
PubMed

Insights

Kluyvera ascorbata, a rare cause of neonatal sepsis, can lead to severe outcomes. This gram-negative bacterium is often resistant to common antibiotics, highlighting the need for effective treatment strategies.

Area of Science:

  • Microbiology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Kluyvera ascorbata, a Gram-negative bacterium from the Enterobacteriaceae family, is typically a commensal organism.
  • Rarely, K. ascorbata can cause severe infections, particularly in vulnerable populations like neonates.
  • This organism often exhibits resistance to first-line antibiotics used in neonatal intensive care units.

Observation:

  • A case report details an extremely low birth weight infant presenting with sepsis, multi-organ dysfunction, shock, and pulmonary hemorrhage on day 4 of life.
  • The infant exhibited elevated C-reactive protein and thrombocytopenia, indicative of severe neonatal sepsis.
  • Blood cultures confirmed the presence of Kluyvera ascorbata.

Findings:

  • Despite aggressive supportive care and meropenem treatment, the infant expired on day 5 of life.
  • The case highlights the potential pathogenicity of K. ascorbata in neonates.
  • Antimicrobial susceptibility patterns indicate that third-generation cephalosporins, fluoroquinolones, and aminoglycosides may be effective against Kluyvera strains.

Implications:

  • This case underscores the importance of considering K. ascorbata in the differential diagnosis of neonatal sepsis, especially with resistant organisms.
  • Further research into the virulence factors and optimal treatment strategies for K. ascorbata infections in neonates is warranted.
  • Enhanced surveillance and antimicrobial stewardship are crucial for managing rare bacterial infections in neonatal intensive care units.

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