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Ghrelin in Critical Illness.

Tathagat Narula1,2, Bennett P deBoisblanc3

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Ghrelin, a peptide hormone, influences appetite and has emerging roles beyond endocrine functions. This review explores its immunomodulatory and non-immune effects, particularly in critical illness.

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Area of Science:

  • Endocrinology
  • Immunology
  • Critical Care Medicine

Background:

  • Ghrelin is a peptide hormone recognized for its endocrine and appetite-regulating functions.
  • Recent research highlights ghrelin's diverse nonendocrine roles.
  • Understanding these functions is crucial for critical illness management.

Purpose of the Study:

  • To review the immunomodulatory effects of ghrelin.
  • To summarize the non-immune-mediated effects of ghrelin.
  • To establish the scientific basis for ghrelin's role in critical illness.

Main Methods:

  • Literature review of existing studies on ghrelin.
  • Analysis of data on ghrelin's immunomodulatory actions.
  • Examination of non-immune-mediated effects of ghrelin.

Main Results:

  • Ghrelin exhibits significant immunomodulatory properties.
  • Non-immune-mediated effects of ghrelin are increasingly recognized.
  • Ghrelin's multifaceted actions are relevant to critical illness pathophysiology.

Conclusions:

  • Ghrelin possesses both immune and non-immune functions.
  • These diverse effects underscore ghrelin's potential role in critical illness.
  • Further research is warranted to fully elucidate ghrelin's therapeutic potential.