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Benefit of Blood Pressure Control in Diabetic Patients

Ulrich Kintscher1

  • 1Center for Cardiovascular Research, CCR, Institute of Pharmacology, Charité - Universitaetsmedizin Berlin, Hessische Str.3-4, 10115, Berlin, Germany, ulrich.kintscher@charite.de.

Current Hypertension Reports
|June 13, 2015
PubMed

Insights

Controlling blood pressure and blood glucose is crucial for patients with both hypertension and diabetes to reduce cardiovascular and renal risks. Recent studies, including ADVANCE-ON, highlight the sustained benefits of blood pressure lowering in this population.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nephrology

Background:

  • Arterial hypertension and diabetes mellitus significantly increase cardiovascular risk.
  • Effective management of blood pressure and blood glucose is essential for mitigating diabetes-related complications.

Purpose of the Study:

  • To discuss new therapeutic targets for blood pressure management in diabetic patients.
  • To evaluate the benefits of blood pressure lowering on macrovascular and microvascular endpoints.
  • To analyze recent findings on long-term blood pressure control in hypertensive diabetics.

Main Methods:

  • Review of clinical trial evidence on blood pressure lowering in diabetes.
  • Evaluation of data from the ADVANCE-ON study.
  • Discussion of current literature and emerging topics.

Main Results:

  • Blood pressure lowering significantly reduces cardiovascular and renal endpoints in diabetic patients.
  • Evidence for microvascular benefits (e.g., retinopathy, albuminuria) is less robust but warrants consideration.
  • The ADVANCE-ON study suggests long-term, sustained benefits of blood pressure management.

Conclusions:

  • Optimizing blood pressure control is a cornerstone of managing patients with coexisting hypertension and diabetes.
  • Further research is needed to clarify the impact on microvascular complications.
  • Sustained blood pressure lowering offers significant protection against major adverse events.

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