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Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice
Published on: February 18, 2022
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Behavioral Measures of Pain Thresholds.
Michael S Minett1,2, Kathryn Quick1, John N Wood1,2
1Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom.
Current Protocols in Mouse Biology
|June 13, 2015
Summary
Mouse models help validate pain targets and develop new pain relief drugs. Researchers use these models to test pain thresholds and screen potential analgesic compounds for various pain types.
Area of Science:
- Pharmacology and Neuroscience
- Animal Models in Pain Research
Background:
- Pain affects a significant portion of the global population.
- Animal models are crucial for understanding pain mechanisms and developing analgesics.
- Current methods involve assessing pain thresholds through behavioral responses to stimuli.
Purpose of the Study:
- To review established mouse models for studying pain.
- To highlight the utility of these models in target validation and drug screening.
- To provide a resource for researchers in pain mechanistics and analgesic development.
Main Methods:
- Discussion of acute mechanical and thermal pain models in mice.
- Description of models for inflammatory, visceral, and neuropathic pain.
- Emphasis on behavioral measures for assessing pain thresholds and responses.
Main Results:
- Mouse models allow for precise phenotyping of transgenic animals.
- Behavioral assays effectively measure changes in pain sensitivity.
- These models are applicable to a wide range of pain conditions.
Conclusions:
- Mouse models are indispensable tools for pain research.
- They facilitate target validation and the screening of analgesic compounds.
- This work provides a foundation for advancing pain management strategies.
