Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.7K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

2.6K
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance.

Neuron·2026
Same author

α-Parvin promotes glucose uptake and metabolism in skeletal muscle with minimal influence on hepatic insulin sensitivity.

Molecular metabolism·2026
Same author

α-Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivity.

bioRxiv : the preprint server for biology·2025
Same author

Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity.

American journal of physiology. Endocrinology and metabolism·2025
Same author

Persistent Postirradiation Skeletal Muscle Protein and Insulin Sensitivity Changes in Nonhuman Primates.

Radiation research·2025

Related Experiment Video

Updated: Apr 10, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.9K

Mouse Models of Bariatric Surgery.

Deng Ping Yin1,2, Kelli L Boyd3,2, Phillip E Williams1,4

  • 1Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.

Current Protocols in Mouse Biology
|June 13, 2015
PubMed
Summary

Bariatric surgery is the most effective obesity treatment. Applying surgical procedures to genetic mouse models enhances understanding of gut health

Keywords:
Roux-en-Y gastric bypassbariatric surgerybiliopancreatic diversionduodenal-jejunal bypassgastric bandingmicesleeve gastrectomy

More Related Videos

A Murine Model of Vertical Sleeve Gastrectomy
06:47

A Murine Model of Vertical Sleeve Gastrectomy

Published on: December 18, 2017

12.0K
A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

6.1K

Related Experiment Videos

Last Updated: Apr 10, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.9K
A Murine Model of Vertical Sleeve Gastrectomy
06:47

A Murine Model of Vertical Sleeve Gastrectomy

Published on: December 18, 2017

12.0K
A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

6.1K

Area of Science:

  • Metabolic disease research
  • Surgical innovation
  • Obesity treatment

Background:

  • Morbid obesity is linked to serious health issues like diabetes and cardiovascular disease.
  • Lifestyle changes and drug therapies are often ineffective for obesity management.
  • Bariatric surgery is the most effective treatment for obesity and related conditions.

Purpose of the Study:

  • To detail bariatric surgical procedures applicable to genetic mouse models.
  • To advance the understanding of the gut's role in metabolic diseases.
  • To provide a resource for researchers studying obesity and metabolic disorders.

Main Methods:

  • Development of genetic mouse models mimicking human bariatric procedures.
  • Implementation of gastric banding, sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), duodenal-jejunal bypass (DJB), and biliopancreatic diversion (BPD).
  • Detailed methodologies for each surgical procedure are provided.

Main Results:

  • Established a suite of bariatric surgical models in mice.
  • Demonstrated the feasibility of applying diverse human bariatric procedures in mice.
  • Created a foundation for further research into gut-metabolic interactions.

Conclusions:

  • Bariatric surgery in mouse models is crucial for understanding metabolic disease.
  • These models offer a platform to investigate the gut's contribution to metabolic disorders.
  • Further research using these models will refine obesity and metabolic disease treatments.