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Related Experiment Video

Updated: Apr 10, 2026

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Published on: August 5, 2011

Hematology Testing in Mice.

Pontus Lundberg¹, Radek Skoda¹

¹Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

Current Protocols in Mouse Biology

|June 13, 2015

Summary

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Mice are vital for studying blood cell development (hematopoiesis), mirroring human processes with key distinctions. This guide details methods for analyzing mouse blood, bone marrow, and spleen cells, including stem cell isolation and transplantation.

Area of Science:

Hematology
Immunology
Stem Cell Biology

Background:

The mouse is a crucial model organism for understanding normal and aberrant hematopoiesis.
While mouse hematopoiesis largely mirrors human processes, significant differences exist.
Standardized methodologies are essential for accurate comparative analysis.

Purpose of the Study:

To provide a comprehensive overview of established techniques for analyzing hematopoiesis in mice.
To detail methods for sample collection and cellular analysis.
To facilitate reproducible research in mouse hematopoietic studies.

Main Methods:

Peripheral blood collection and analysis.
Flow cytometry for peripheral blood, bone marrow, and spleen cell characterization.

Keywords:

bone marrow transplantation hematopoiesis hematopoietic mouse hematology peripheral blood stem cell

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Last Updated: Apr 10, 2026

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Published on: August 5, 2011

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

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Homing of Hematopoietic Cells to the Bone Marrow

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Isolation and transplantation of bone marrow stem cells for functional assessment.

Main Results:

Detailed protocols for each method are presented.
The applicability of these methods to various hematopoiesis research questions is highlighted.
The study establishes a foundational resource for mouse hematopoiesis research.

Conclusions:

The described methods offer a robust framework for investigating mouse hematopoiesis.
Accurate analysis of mouse hematopoietic systems is critical for translational research.
This protocol serves as a valuable resource for researchers utilizing mouse models.