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[Pathophysiological mechanisms of vascular calcification]

Lucie Hénaut1, Romuald Mentaverri2, Sophie Liabeuf3

  • 1Unité Inserm 1088 : MP3CV « Mécanismes physiopathologiques, causes et conséquences des calcifications vasculaires ». Université de Picardie Jules Verne, France.

Annales De Biologie Clinique
|June 13, 2015
PubMed

Insights

Vascular calcification (VC) is a degenerative vessel wall disease linked to aging and chronic conditions. This review details the active cellular processes and key regulators involved in VC formation.

Area of Science:

  • Cardiovascular Biology
  • Pathology
  • Biomineralization

Context:

  • Vascular calcification (VC) is a degenerative arterial disease associated with aging, atherosclerosis, diabetes, and chronic kidney disease.
  • VC significantly increases the risk of mortality and cardiovascular disease.
  • Previously viewed as passive mineral precipitation, VC is now understood as an active, regulated cellular process.

Purpose:

  • To review current knowledge on the mechanisms of vascular calcification.
  • To detail the roles of key cellular actors modulating VC formation.

Summary:

  • Vascular calcification involves active, regulated cellular processes similar to bone formation.
  • Key cellular and molecular pathways drive the development of VC.
  • Understanding these mechanisms is crucial for therapeutic development.

Impact:

  • Provides a comprehensive overview of VC pathogenesis.
  • Highlights the cellular basis of vascular calcification.
  • Informs future research into preventing and treating VC and its cardiovascular consequences.

Keywords:
chronic kidney diseasediabetesintimamediaosteoblastvascular calcificationvascular smooth muscle cell

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